· 1 Musim reguler
o 1.1 Klasemen akhir
§ 1.1.1 Konferensi Pangeran Wales
§ 1.1.2 Konferensi Clarence Campbell
o 1.2 Pemimpin penilaian
· 2 playoff Piala Stanley
o 2.1 Braket playoff
o 2.2 Final
· 3 penghargaan NHL
o 3.1 Tim All-Star
· 4 Permainan pertama
· 5 Pertandingan terakhir
· 6 Halaman terkait
· 7 Referensi
Catatan: GP = Permainan yang dimainkan, W = Menang, L = Kalah, T = Ties, Poin = Poin, GF = Gol untuk, GA = Gol melawan, PIM = Penalti dalam menit
Catatan: Tim yang lolos ke babak playoff disorot dengan huruf tebal
| Divisi Adams | GP | W | L | T | Pts | GF | GA | PIM |
| Buffalo Sabres | 80 | 39 | 20 | 21 | 99 | 327 | 250 | 1194 |
| 80 | 37 | 30 | 13 | 87 | 316 | 272 | 1836 | |
| Minnesota North Stars | 80 | 35 | 28 | 17 | 87 | 291 | 263 | 1624 |
| Quebec Nordiques | 80 | 30 | 32 | 18 | 78 | 314 | 318 | 1524 |
| Toronto Maple Leafs | 80 | 28 | 37 | 15 | 71 | 322 | 367 | 1830 |
| Divisi Norris | GP | W | L | T | Pts | GF | GA | PIM |
| Montreal Canadiens | 80 | 45 | 22 | 13 | 103 | 332 | 232 | 1398 |
| Los Angeles Kings | 80 | 43 | 24 | 13 | 99 | 337 | 290 | 1627 |
| 80 | 31 | 33 | 16 | 78 | 304 | 315 | 1660 | |
| Pittsburgh Penguins | 80 | 30 | 37 | 13 | 73 | 302 | 345 | 1807 |
| Hartford Whalers | 80 | 21 | 41 | 18 | 60 | 292 | 372 | 1584 |
| Detroit Red Wings | 80 | 19 | 43 | 18 | 56 | 252 | 339 | 1687 |
| Divisi Patrick | GP | W | L | T | Pts | GF | GA | PIM |
| Kepulauan New York | 80 | 48 | 18 | 14 | 110 | 355 | 260 | 1442 |
| 80 | 41 | 24 | 15 | 97 | 313 | 249 | 2621 | |
| 80 | 39 | 27 | 14 | 92 | 329 | 298 | 1450 | |
| New York Rangers | 80 | 30 | 36 | 14 | 74 | 312 | 317 | 1981 |
| Washington Capitals | 80 | 26 | 36 | 18 | 70 | 286 | 317 | 1872 |
| Divisi Smythe | GP | W | L | T | Pts | GF | GA | PIM |
| Louis Blues | 80 | 45 | 18 | 17 | 107 | 352 | 281 | 1657 |
| Vancouver Canucks | 80 | 28 | 32 | 20 | 76 | 289 | 301 | 1892 |
| 80 | 29 | 35 | 16 | 74 | 328 | 327 | 1544 | |
| Colorado Rockies | 80 | 22 | 45 | 13 | 57 | 258 | 344 | 1418 |
| Winnipeg Jets | 80 | 9 | 57 | 14 | 32 | 246 | 400 | 1191 |
Catatan: GP = Permainan yang dimainkan; G = Gol; A = Assists; Pts = Poin
| Pemain | Tim | GP | G | A | Pts | PIM |
| Edmonton Oilers | 80 | 55 | 109 | 164 | 28 | |
| Marcel Dionne | Los Angeles Kings | 80 | 58 | 77 | 135 | 70 |
| Kent Nilsson | Calgary Flames | 80 | 49 | 82 | 131 | 26 |
| Mike Bossy | Kepulauan New York | 79 | 68 | 51 | 119 | 32 |
| Dave Taylor | Los Angeles Kings | 72 | 47 | 65 | 112 | 130 |
| Peter Stastny | Quebec Nordiques | 77 | 39 | 70 | 109 | 37 |
| Charlie Simmer | Los Angeles Kings | 65 | 56 | 49 | 105 | 62 |
| Mike Rogers | Hartford Whalers | 80 | 40 | 65 | 105 | 32 |
| Bernie Federko | Louis Blues | 78 | 31 | 73 | 104 | 47 |
| Jacques Richard | Quebec Nordiques | 78 | 52 | 51 | 103 | 39 |
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| Babak Penyisihan | Perempat final | Semi-final | Final Piala Stanley | ||||||||||||||||
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| 1 | Kepulauan New York | 3 |
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| 16 | Toronto Maple Leafs | 0 |
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| 1 | Kepulauan New York | 4 |
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| 14 | 2 |
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| 2 | Louis Blues | 3 | ||||||||||||||||||
| 15 | Pittsburgh Penguins | 2 |
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| 1 | Kepulauan New York | 4 |
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| 13 | New York Rangers | 0 |
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| 3 | Montreal Canadiens | 0 |
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| 14 | 3 |
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| 2 | Louis Blues | 2 | |||||||||||||||||
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| 13 | New York Rangers | 4 |
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| 4 | Los Angeles Kings | 1 | ||||||||||||||||||
| 13 | New York Rangers | 3 |
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| 1 | Kepulauan New York | 4 | |||||||||||||||||
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| 9 | Minn. Bintang Utara | 1 | |||||||||||||||||
| 5 | Buffalo Sabres | 3 |
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| 12 | Vancouver Canucks | 0 |
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| 5 | Buffalo Sabres | 1 | |||||||||||||||||
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| 9 | Minn. Bintang Utara | 4 |
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| 11 | Quebec Nordiques | 2 |
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| 9 | Minn. Bintang Utara | 4 |
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| 7 | 3 |
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| 10 | 0 |
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| 7 | 4 |
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| 8 | 0 | |||||||||||||||||||
| 9 | Minn. Bintang Utara | 3 |
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New York Islanders vs Minnesota North Stars
| Tanggal | Pengunjung | Skor | Rumah | Skor |
| 12 Mei | Minnesota | 3 | New York | 6 |
| 14 Mei | Minnesota | 3 | New York | 6 |
| 17 Mei | New York | 7 | Minnesota | 5 |
| 19 Mei | New York | 2 | Minnesota | 4 |
| 21 Mei | Minnesota | 1 | New York | 5 |
New York memenangkan seri 4-1.
| Montreal Canadiens | |
| Clarence S. Campbell Bowl: | Kepulauan New York |
| Art Ross Memorial Trophy: | |
| Blake Dunlop, St Louis Blues | |
| Trofi Memorial Calder: | Peter Stastny, Quebec Nordiques |
| Butch Goring, New York Islanders | |
| Frank J. Selke Trophy: | Bob Gainey, Montreal Canadiens |
| Gordon "Red" Berenson, St Louis Blues | |
| Randy Carlyle, Pittsburgh Penguins | |
| Rick Kehoe, Pittsburgh Penguins | |
| Penghargaan Lester B. Pearson: | Mike Liut, St Louis Blues |
| Penghargaan NHL Plus/Minus: | Brian Engblom, Montreal Canadiens |
| Piala Vezina: | Denis Herron, Michel Larocque, & Richard Sevigny, Montreal Canadiens |
| Trofi Lester Patrick: | Charles M. Schulz |
| Tim Pertama | Posisi | Tim Kedua |
| Mike Liut, St Louis Blues | G | Mario Lessard, Los Angeles Kings |
| Denis Potvin, New York Islanders | D | Larry Robinson, Montreal Canadiens |
| Randy Carlyle, Pittsburgh Penguins | D | Ray Bourque, Boston Bruins |
| C | Marcel Dionne, Los Angeles Kings | |
| Mike Bossy, New York Islanders | RW | Dave Taylor, Los Angeles Kings |
| Charlie Simmer, Los Angeles Kings | LW | Bill Barber, Philadelphia Flyers |
Berikut ini adalah daftar pemain yang memainkan pertandingan NHL pertama mereka pada tahun 1980-81 (terdaftar dengan tim pertama mereka, bintang (*) menandai debut di babak playoff):
Berikut ini adalah daftar pemain yang memainkan pertandingan terakhir mereka di NHL pada tahun 1980-81 (terdaftar dengan tim terakhir mereka):